Antibiotic Treatment of Severe or Complicated Yersiniosis
Most yersiniosis episodes are self-limiting, but severe or prolonged disease, suspected bacteremia, and infection in immunocompromised individuals require targeted antibiotic therapy. This protocol addresses those complicated presentations.
Clinical Scenario
Antibiotic treatment is indicated in severe or complicated diarrheal infection — particularly when bacteremia is present or suspected, or when the patient is immunocompromised. In these settings, empiric treatment selection must account for organism susceptibility patterns.
Treatment Approach (partial)
The primary antibiotic class used in severe yersiniosis is quinolones. Alternative regimens exist and are selected based on susceptibility, disease severity, and patient factors.
The complete regimen — including alternative antibiotic combinations, sequencing, and clinical decision points — is in the full protocol.
References
DOI: 10.3390/microorganisms13051133
- Severe and prolonged disease may require antibiotics, primarily quinolones; however, aminoglycosides or tetracyclines in combination with trimethoprim–sulfamethoxazole (TMP-SMX) have also been used.
- Most organisms are sensitive to aminoglycosides and fluoroquinolones.
- However, antibiotic treatment is recommended only in severe or complicated diarrheal infections, especially in the case of concomitant or suspected bacteremia or in immunocompromised individuals.
- Third-generation cephalosporins +/− TMP-SMX.
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