Treatment of Wilson's Disease with Liver Cirrhosis, Fibrosis, Liver Failure, or Haemolysis

This protocol addresses Wilson's disease presenting with significant hepatic involvement — including liver cirrhosis significant liver fibrosis liver failure or haemolysis. These features indicate active copper-related organ injury requiring a specific first-line treatment approach.

In patients with significant liver disease — whether fibrosis, established cirrhosis, liver failure, or concurrent haemolysis — the choice of treatment strategy is guided by the severity of hepatic involvement. Guidelines specifically direct the first-line approach in this sub-population.