Treatment of Waldenstrom's Macroglobulinemia with Symptomatic Hyperviscosity Requiring Immediate Disease Control
Clinical Scenario
This protocol addresses Waldenstrom macroglobulinemia presenting with symptomatic hyperviscosity — a situation in which prompt intervention is required to achieve immediate disease control.
Treatment Approach
When immediate disease control is needed, an initial procedural intervention is part of the recommended first-line management strategy. The complete approach — including sequencing, selection criteria, and subsequent steps — is outlined in the full protocol.
References
DOI: 10.6004/jnccn.2024.0001
According to the NCCN Panel, for patients requiring immediate disease control, such as those with symptomatic hyperviscosity, initial plasmapheresis is recommended.