Treatment of Vulvar Lichen Sclerosus in Lichen Sclerosus with Secondary Infection of the Genital Skin

When lichen sclerosus is complicated by secondary infection of the genital skin, the management approach must address that infection as a priority alongside the underlying condition.

Clinical Scenario

This protocol applies to patients with lichen sclerosus presenting with secondary infection of the genital skin. The presence of secondary infection shapes the immediate treatment strategy and must be resolved before standard long-term management can proceed effectively.

Treatment Approach

Management involves a topical steroid preparation used in combination with agents targeting the secondary infection — complete agent selection, application guidance, and course duration are specified in the full protocol.

Goal: Clearance of secondary genital skin infection
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References

DOI: 10.1111/jdv.18102

An ultra-potent or potent topical steroid preparation combined with antibacterial and antifungal agents for example gentamycin or fucidic acid and nystatin or azole antifungals or an alternative preparation that combats secondary infection may be appropriate if secondary infection is a concern.

These should only be used for a short period of time to clear infection.

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