What Is the Treatment of Vitamin B3 Deficiency?

Vitamin B3 deficiency presents with characteristic multi-system involvement. The first-line regimen addresses both systemic repletion and cutaneous manifestations, with measurable clinical response expected within days of initiating treatment.

Treatment Approach

Management centres on oral B-vitamin supplementation, with additional micronutrient support considered alongside it. Topical skin care — focusing on barrier protection and photoprotection — is also part of the approach. The complete regimen, including sequencing, duration, and all components, is available in the full structured protocol.

Treatment Goals

The target is clinical improvement within a few days of starting treatment, with skin lesions expected to subside first as an early marker of response.

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References

The standard treatment of pellagra is oral nicotinamide (niacinamide) supplementation.
The commonly accepted dosage regimen is 300 mg daily divided into 3–4 doses.
Therapy should last 3–4 weeks.
It is vital to administer preparations of other group B vitamins as well, because patients with pellagra often suffer from multivitamin deficiencies.
Zinc supplementation may be considered too.
Topical treatment is based on the application of emollients (to reduce skin dryness) and photoprotection, according to the commonly accepted principles.
Improvement usually occurs within a few days, with skin lesions subsiding as first.

DOI: 10.24425/fmc.2021.138956

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