This protocol covers resectable locoregional VIPoma — a VIP-secreting pancreatic neuroendocrine tumor confined to the head of the pancreas — where both symptom control and surgical cure are central objectives of management.
A VIP-secreting pancreatic neuroendocrine tumor localised to the head of the pancreas, resectable and locoregional in extent. The presentation is characterised by severe secretory watery diarrhea, hypokalemia, and significant electrolyte and fluid disturbances.
Resolution of severe watery diarrhea, correction of hypokalemia, and restoration of electrolyte and fluid balance — together with definitive surgical control of the tumor.
Management combines medical therapy with somatostatin analogues to achieve symptom and tumor control, correction of metabolic disturbances, and surgical resection — the specific procedure for pancreatic head tumors is well defined in the full protocol. Criteria for alternative surgical approaches in select cases are addressed there as well.