Ventricular septal defect
ICD-10 Q21.0 ICD-11 LA88.4

Treatment of VSD with Progressive Aortic Regurgitation Due to Aortic Valve Cusp Prolapse

A subset of patients with ventricular septal defect develop prolapse of an aortic valve cusp, leading to progressive aortic regurgitation. This complication changes the clinical trajectory and requires a specific management approach beyond routine VSD surveillance.

In this scenario, the VSD acts as a substrate for cusp prolapse, and the resulting progressive aortic regurgitation drives both haemodynamic deterioration and the decision to intervene. The presence of worsening AR in this setting is the key indicator that guides the treatment strategy.

A surgical approach is considered in this situation — the full structured protocol outlines the specific operative strategy and decision criteria. Complete regimen, indications, and sequencing available via the link below.

References
DOI: 10.1093/eurheartj/ehaa554

In patients with VSD-associated prolapse of an aortic valve cusp causing progressive AR, surgery should be considered.

Surgical closure can be performed with low operative mortality (1-2%) and good long-term results.

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