This clinical scenario concerns metastatic uveal melanoma in which the extent of spread is limited — oligometastatic disease with metastases confined entirely to the liver and no detectable extrahepatic involvement.
Metastatic uveal melanoma, oligometastatic pattern. All metastases are confined to the liver; there is no extrahepatic disease. This well-defined distribution identifies a subset of patients for whom localised, organ-directed management warrants consideration alongside systemic options.
The approach for this scenario centres on local liver-directed interventions, with the choice of modality guided by patient eligibility and individual disease characteristics.
Full regimen options, selection criteria, and clinical guidance are available in the complete protocol below.
DOI: 10.1016/j.esmoop.2026.106888