Uveal Melanoma with Multifocal Liver Metastases Confined to the Liver
When metastatic uveal melanoma presents with multifocal hepatic involvement and disease remains entirely within the liver — with no extrahepatic spread — this hepatic-confined distribution shapes a distinct clinical approach.
Clinical scenario: Metastatic uveal melanoma with multifocal liver metastases confined to the liver and no extrahepatic metastases. The absence of extrahepatic disease is a defining feature that informs patient eligibility for certain interventional strategies.
In this setting, regional liver-directed therapy is a primary consideration — specific hepatic interventional approaches exist for eligible patients — and systemic treatment options may also be relevant depending on individual patient characteristics. The full protocol details which approaches apply and how they are selected.
References
DOI: 10.1016/j.esmoop.2026.106888
- Patients with multifocal liver metastases confined to the liver should be considered for regional liver-directed therapies (PHP or IHP) [II, B].
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