This protocol addresses the management of uterine sarcoma arising in the context of low-grade endometrial stromal sarcoma (LG-ESS) — a distinct histological subtype that accounts for approximately 20% of all uterine sarcomas and is typically diagnosed around a mean age of 50 years.
In cases of disease progression and/or high-grade transformation occurring on endocrine therapy, a systemic treatment approach drawn from high-grade uterine sarcoma protocols may be considered in selected patients. The full algorithm, options, and selection criteria are available in the complete protocol.
DOI: 10.1136/ijgc-2024-005823
LG-ESS account for approximately 20% of all uterine sarcomas, and are diagnosed at a mean age of around 50 years.
Following disease progression and/or high-grade transformation on endocrine therapy (including several lines), chemotherapy regimens as per high-grade tumors could be considered in selected cases (V, C).
View source ↗