This protocol addresses primary urethral carcinoma with non-squamous cell carcinoma histology at locally advanced stage: T3 or T4 primary tumour with regional lymph node involvement (N1–N2) and no distant metastasis. This is a first-line treatment scenario.
The patient presents with primary urethral carcinoma of non-squamous cell carcinoma histology, staged T3–T4, N1–N2, M0. Lymph node-positive, locally advanced disease at this stage requires a multimodal strategy. Retrospective evidence indicates that cisplatin-based chemotherapy can provide prolonged survival even in lymph node-positive disease, and that surgical consolidation following chemotherapy plays a critical role in achieving long-term outcomes.
Management involves inductive cisplatin-based combination chemotherapy as the initial systemic step, followed by consolidative surgery. The complete regimen, sequencing details, and specific guidance for urothelial carcinoma histology — including reference to perioperative systemic therapy recommendations — are set out in the full protocol.