What is the first-line treatment for upper limb deep vein thrombosis?

Clinical Scenario

This is a first-line protocol for the management of upper limb deep vein thrombosis (ULDVT) — thrombosis occurring in the deep veins of the arm or axillosubclavian region.

Treatment Approach

Management centres on acute anticoagulation therapy, with an initial parenteral phase followed by a defined course of oral anticoagulation — the full agent selection, sequencing, and duration are set out in the complete protocol.

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References

DOI: 10.1161/circulationaha.111.051276

Anticoagulation therapy should be undertaken with a once-daily regimen of LMWH or fondaparinux for at least 5 days, followed by vitamin K antagonists for at least 3 months.

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