Treatment of Turner Syndrome with Short Stature Diagnosed After Age 12
When Turner syndrome is identified after the age of 12 in a girl who still has short stature and open epiphyses, the growth window remains open — and the treatment approach is tailored specifically to this later-diagnosed scenario.
Clinical Scenario
This protocol applies to girls with a confirmed Turner syndrome diagnosis made after 12 years of age who present with short stature and demonstrable remaining growth potential (open epiphyses). Recognising this specific combination — later diagnosis plus active growth potential — is key to selecting the appropriate management strategy.
Treatment Approach
Current evidence supports a combined hormonal strategy. The approach involves an estrogen-based therapy used alongside a growth-directed hormonal intervention — with the two initiated in a coordinated fashion. The complete regimen, including agent selection, sequencing, and monitoring, is available in the full protocol.
References
DOI: 10.1093/ejendo/lvae050
In individuals with a later diagnosis (>12 years) who have short stature and remaining growth potential, we suggest initiating treatment with low dose 17β-estradiol (E2) simultaneously with GH.
View source ↗