This protocol addresses tularemia in the neonatal period, specifically defined by age: full-term infants aged 28 days or younger, and infants born prematurely who have reached 37–44 weeks postmenstrual age. The patient's age at this stage directly informs both agent selection and the preferred route of administration.
First-line management in this age group involves antimicrobial monotherapy. For ill neonates, intravenous administration is preferred where possible, with criteria for transitioning to oral therapy once clinical improvement is evident. A presumptive treatment strategy also exists for ill-appearing neonates with a specific maternal exposure history.