Thyroid storm can present with severe central nervous system involvement — restlessness, delirium, psychosis, agitation, convulsions, somnolence, or coma. When these features do not resolve with initial management, an escalated protocol is indicated.
Thyroid storm often presents with CNS manifestations such as restlessness, delirium, psychosis, somnolence, convulsion, and coma. This protocol addresses patients in whom those features persist despite first-line therapy.
The preceding treatment step targeted control of restlessness, delirium, and psychosis using antipsychotic medication (oral or injectable), and cessation of convulsions using benzodiazepine (diazepam) intravenously as the first-line anticonvulsant agent.
When those goals — control of CNS agitation, delirium, and psychosis, and cessation of convulsions — are not achieved, this next-line protocol applies.