Hereditary (congenital) thrombotic thrombocytopenic purpura presents particular clinical challenges in the setting of pregnancy. Evidence-based guidance addresses whether prophylactic treatment should be used and, if so, what approach is preferred.
This protocol applies to patients with hereditary/congenital TTP (cTTP) who are pregnant. Current guidance recommends prophylactic treatment over no prophylactic treatment in this population.
For pregnant patients with cTTP, a prophylactic plasma-based intervention is recommended.
DOI: 10.1111/jth.15010
For patients with cTTP who are pregnant, the panel recommends prophylactic treatment over no prophylactic treatment.
For patients with cTTP who are pregnant, the panel suggests prophylactic treatment with plasma infusion over FVIII products.