Abdominal Pain in Indolent or Smoldering Systemic Mastocytosis

Clinical scenario

This protocol is for patients with indolent (ISM) or smoldering (SSM) systemic mastocytosis who experience gastrointestinal symptoms driven by their disease. Treatment in this setting is primarily directed toward symptom control and anaphylaxis prevention.

Abdominal pain Cramping Diarrhea Heartburn Nausea / vomiting

The protocol involves sodium cromolyn as the agent for gastrointestinal symptom management. The complete regimen — including schedule, timing relative to meals, and step placement — is in the full protocol below.

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References

DOI: 10.1002/ajh.26962

Treatment goals for ISM patients are primarily directed toward anaphylaxis prevention/symptom control/osteoporosis treatment.

100–200 mg QID 30 min before meals and bedtime

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