Treatment of Indolent or Smoldering Systemic Mastocytosis with Abdominal Pain

In patients with indolent systemic mastocytosis (ISM) or smoldering systemic mastocytosis (SSM), gastrointestinal symptoms — abdominal pain, cramping, diarrhea, heartburn, nausea, and vomiting — are a primary treatment concern. Symptom control is a central management objective in this population.

Abdominal pain and diarrhea are among the most burdensome complaints in ISM and SSM. Treatment goals for these patients are primarily directed toward symptom control alongside prevention of other systemic complications.

Evidence-based first-line management of GI symptoms in this setting centres on H2-receptor antagonist therapy. The complete structured protocol — including agent selection, alternatives, and the full clinical algorithm — is available in the full regimen.

Full regimen details, including sequencing and additional options, are available via the link below.