This protocol addresses a specific presentation of apparent mineralocorticoid excess in adolescents through adults: a high cortisol/cortisone (F/E) ratio with low serum cortisone, suppressed plasma renin, and increased urinary potassium excretion — but without overt hypertension.
The structured regimen for this normotensive presentation includes specific dietary modification as a core intervention. The complete protocol with full detail is available below.
Subjects with NC-AME are characterized by a high F/E ratio, low E levels, normal to elevated blood pressure, low plasma renin and increased urinary potassium excretion.
Patients with normotensive NC-AME should have medical surveillance and a low-sodium/high-potassium diet recommendation.
DOI: 10.1210/clinem/dgz315
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