This protocol covers superior vena cava syndrome that has not responded adequately to initial endovascular management. When balloon angioplasty with stent placement fails to reach its clinical targets, open surgical reconstruction becomes the recognised next-line intervention.
The first-line approach — balloon angioplasty of the lesion with concomitant covered or bare metal stent placement, plus anticoagulation or antiplatelet therapy — failed to achieve its targets: rapid symptomatic relief of SVC obstruction (patient becoming asymptomatic) and reduction of the pressure gradient between the innominate veins and the right atrium to 1–2 mm Hg.
DOI: 10.1016/j.jvsv.2026.102491
Open surgery remains a viable option using spiral saphenous vein graft, femoral vein, and expanded polytetrafluoroethylene graft for those who are not candidates for endovascular interventions or fail after repeat interventions.
View source ↗