Sublingual gland cancer
ICD-10 C08.1 · ICD-11 2B68&XA51Q9

Treatment of Resectable Sublingual Gland Cancer with No Cervical Lymph Node Involvement (cN0, M0)

This protocol addresses resectable sublingual gland cancer in patients with no clinical or radiological evidence of cervical lymph node metastasis (cN0) and no distant metastasis (M0) — a presentation where curative-intent surgery is the central consideration.

Clinical Scenario

Treatment Approach

The standard approach involves surgical resection of the primary tumour — with the surgical access technique chosen according to tumour characteristics — combined with elective management of the neck. The full protocol specifies the approach options and the extent of neck dissection required.

Complete approach selection criteria, technique details, and neck dissection levels are defined in the structured protocol.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.esmoop.2022.100602

Surgery is the mainstay of treatment for primary resectable disease with the traditional open approach being the most widely used, although endoscopic and robot-assisted approaches have recently been described.

In oral cavity (levels I, II, III and IV) and oropharyngeal (levels II, III and IV) minor SGC, and in high-grade MEC and AdCC, the occult rates largely exceed 20% and END is indicated.

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