Hyperinfection syndrome and disseminated strongyloidiasis represent the most severe presentations of Strongyloides infection. These situations require prompt, structured management guided by a specific clinical protocol.
This protocol is indicated for patients presenting with hyperinfection syndrome or disseminated strongyloidiasis — a high-acuity situation requiring urgent and systematic clinical intervention.
Where clinically feasible, the approach involves reduction or cessation of immunosuppressive therapy, combined with antiparasitic treatment with ivermectin. The appropriate route of administration is determined by the patient's clinical condition and their ability to tolerate therapy.
Confirmed clearance of Strongyloides, demonstrated by negative stool and/or sputum examinations.