This protocol addresses rat bite fever caused by Streptobacillus moniliformis complicated by infective endocarditis — a serious presentation that requires a specific antimicrobial strategy distinct from uncomplicated rat bite fever.
Management involves dual antimicrobial therapy, combining a high-dose penicillin with an aminoglycoside antibiotic. The complete regimen — including agent selection, weight-based paediatric dosing, adult dosing, susceptibility-guided adjustments, and treatment duration — is detailed in the full structured protocol.
Complete regimen and dosing guidance available in the full protocol →Patients with S. moniliformis endocarditis require dual therapy with high-dose penicillin G in combination with streptomycin or gentamicin.
DOI: 10.1128/CMR.00016-06
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