Treatment of Streptobacillosis (Rat Bite Fever) in Children Under 18 Years — Not Penicillin-Allergic

Clinical Scenario

This protocol covers Streptobacillosis (rat bite fever) in a child under 18 years of age who has no penicillin allergy. Pediatric patients require age-specific dosing and a structured sequential approach that differs from adult management.

Treatment Approach

First-line management uses a sequential parenteral-to-oral penicillin regimen, weight-adjusted for the pediatric patient. The complete protocol — including specific agents, weight-based thresholds, and full duration — is available via the link below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1128/CMR.00016-06

Children should receive 20,000 to 50,000 IU/kg of body weight/day (12 to 30 mg/kg/day) of intravenous penicillin G for 5 to 7 days, followed by 7 days of oral penicillin V, 25 to 50 mg/kg/day (maximum, 3 g/day) divided four times per day.

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