Treatment of Streptobacillosis in Adults (Age 18+) with Rat Bite Fever — Not Penicillin-Allergic

This protocol covers the management of Streptobacillosis presenting as rat bite fever in adult patients aged 18 years or older who have no history of penicillin allergy.

Clinical scenario: Adult patient (age 18 years or older) presenting with rat bite fever due to Streptobacillosis, with no penicillin allergy.

Treatment Approach

Management in this population involves penicillin G therapy. The full regimen — including route, dosing, duration, and response-based dose adjustments — is specified in the complete protocol.

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References

DOI: 10.1128/CMR.00016-06

Adults with rat bite fever should receive 400,000 to 600,000 IU/day (240 to 360 mg) of intravenous penicillin G for at least 7 days, but this dose should be increased to 1.2 million IU/day (720 mg) if no response is seen within 2 days.

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