Treatment of Resectable Gastric Cancer, Stage IB–III

Clinical Scenario

This protocol applies to patients with resectable gastric cancer at stage IB through stage III. In this setting, curative-intent treatment is the goal, and the recommended approach integrates systemic therapy with definitive surgery.

Recommended Approach

Management centres on peri-operative chemotherapy combined with radical gastrectomy with D2 lymphadenectomy, carried out at a high-volume surgical centre. The full protocol specifies which chemotherapy regimen applies and how it is structured around surgery.

Complete regimen options, patient-fitness criteria, and surgical margin guidance are detailed in the full structured protocol below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.annonc.2022.07.004

For stage IB-III gastric cancer, peri-operative therapy and radical gastrectomy is recommended [I, A].
Peri-operative (pre- and post-operative) ChT is recommended for patients with stage IB resectable gastric cancer [I, A].
For stage IB-III disease, radical gastrectomy is indicated.
Patients should undergo D2 resection in a high-volume surgical centre [II, B].

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