This protocol applies to osteoarticular sporotrichosis — a presentation of Sporotrichosis in which the infection involves the bones and/or joints. This form of the disease follows a distinct clinical course and requires a specifically structured antifungal strategy.
Osteoarticular sporotrichosis is managed with an initial course of parenteral antifungal therapy; once a favorable clinical response is achieved, treatment transitions to a prolonged oral antifungal regimen — the complete agent selection, step-down criteria, and total duration are specified in the full protocol.
DOI: 10.1086/522765
Amphotericin B, given as a lipid formulation at 3–5 mg/kg daily, or amphotericin B deoxycholate, administered at a dosage of 0.7–1.0 mg/kg daily, can be used for initial therapy (B-III).
After the patient has shown a favorable response, therapy can be changed to itraconazole administered at a dosage of 200 mg orally twice daily to complete a total of at least 12 months of therapy (B-III).
Itraconazole administered at a dosage of 200 mg orally twice daily for at least 12 months is recommended (A-II).
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