Treatment of WHO Grade III (Anaplastic) Ependymoma of the Spinal Cord

Clinical Scenario

This protocol applies to spinal cord ependymoma classified as WHO grade III (anaplastic) — a high-grade histological designation that directly determines post-surgical management strategy.

Specific Situation

The anaplastic grade of this tumour has implications for treatment planning regardless of how completely surgical resection was achieved. Extent of resection alone does not determine whether adjuvant therapy is required in this setting.

Treatment Approach

Management of WHO grade III anaplastic spinal cord ependymoma involves a postoperative radiation therapy component. The full structured protocol — including the complete treatment pathway, sequencing, and the supporting evidence base — is available via the link below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1093/neuonc/nox166

In case of WHO grade III (anaplastic) ependymomas, postoperative radiotherapy with doses of 45–54 Gy is recommended regardless of the extent of resection.

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