This protocol covers the management of WHO grade II ependymoma of the spinal cord — a specific histological classification that directly determines the treatment strategy and post-operative decision-making.
Management centres on surgical intervention aimed at maximal removal of the spinal cord tumor. The extent of resection achieved at surgery is a pivotal factor in determining what follows.
DOI: 10.1093/neuonc/nox166
Gross total resection is the goal of spinal ependymoma surgery.
In case of WHO grade II ependymomas following gross total resection, a watch-and-wait strategy is recommended.
In case of incomplete resection of a WHO grade II ependymoma, postoperative local radiotherapy is recommended with doses of 45–54 Gy.
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