This protocol addresses solid papillary carcinoma of the breast with evidence of invasion arising in the context of inflammatory breast cancer or locally advanced breast cancer — a clinically distinct presentation that shapes the overall treatment sequence.
The majority of inflammatory breast cancers follow a defined multimodal pathway: neo-adjuvant chemotherapy is delivered first, followed by definitive mastectomy, with postoperative management completing the sequence. This protocol applies to the postoperative phase of that pathway.
Management in this setting centres on postoperative chest wall radiotherapy delivered via an established technique. Specific dose schedules, fractionation, and delivery method are detailed in the full structured protocol…
The majority of inflammatory cancers will be treated with neo-adjuvant chemotherapy, definitive mastectomy followed by postoperative radiotherapy.
Radiotherapy doses of 40 Gy in 15 fractions or 50 Gy in 25 fractions via tangent pair to chest wall or direct electron beam therapy to chest wall should be given.
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