Solid papillary carcinoma of the breast with evidence of invasion is a breast malignancy in which invasive spread has been confirmed. Once invasion is established, systemic adjuvant treatment is indicated alongside local management. The choice of regimen is guided by clinical factors, including nodal status and individual patient characteristics.
Management centres on adjuvant chemotherapy. Multiple standard multi-drug combination regimens are available, with the selection informed by nodal involvement and whether particular agents are contraindicated — the full regimen, its sequencing, and the decision algorithm are detailed in the structured protocol.