Solid papillary carcinoma of breast with evidence of invasion
ICD-10 C50 · ICD-11 2C64

Solid Papillary Carcinoma of Breast with Evidence of Invasion — What Comes After Surgical Treatment

Clinical Scenario

This protocol addresses patients with solid papillary carcinoma of the breast with evidence of invasion who have completed the initial surgical treatment phase. Once surgery is complete and the margin status is known, a defined next treatment step follows.

Previous Treatment Line

The initial line is surgical resection — either breast-conserving surgery or mastectomy, with axillary staging. The surgical aim is a clear radial resection margin of at least 1 mm. After that phase has been completed, management proceeds to this protocol.

Next Step: Treatment Overview

Following surgical resection, adjuvant radiotherapy is the central component of the next management phase — the complete protocol specifies the approach based on surgery type and patient risk profile.

Instant Access to Structured Evidence-Based Regimens

References

  1. Patients with early invasive breast cancer who have had breast conserving surgery with clear margins should have breast radiotherapy.
  2. Following breast conserving surgery, postoperative radiotherapy to the intact breast should be delivered via a tangent pair.
  3. Standard dose will be 40 Gy in 15 fractions.
  4. In large volume breasts, consideration should be given to treatment with 50 Gy in 25 fractions.
  5. Adjuvant chest wall radiotherapy should be given to patients with early invasive breast cancer who have had a mastectomy and are at a high risk of local recurrence.
  6. Radiotherapy doses of 40 Gy in 15 fractions or 50 Gy in 25 fractions via tangent pair to chest wall or direct electron beam therapy to chest wall should be given.
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