Renal tubular involvement is a recognised systemic manifestation of Sjögren syndrome. When distal renal tubular acidosis (dRTA) or hypokalemia is present, specific metabolic correction is required alongside broader disease management.
This protocol applies to patients with Sjögren syndrome who have renal tubular involvement — specifically distal renal tubular acidosis or hypokalemia. Management of systemic involvement is calibrated to organ-specific severity according to ESSDAI definitions. Without appropriate intervention, this renal manifestation can progress to serious sequelae including renal failure and hypokalaemic paralysis.
The protocol targets the underlying metabolic disturbances. Supplementation is central to the approach, with separate agents directed at correcting the acid–base disturbance and the electrolyte deficit — but the full regimen, agent selection, and monitoring framework remain in the structured protocol.
DOI: 10.1136/annrheumdis-2019-216114
Treatment of systemic disease should be tailored to organ-specific severity using the ESSDAI definitions.
Renal failure; rapidly-progressive glomerulonephritis; hypokalaemic paralysis.
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