Treatment of Sjögren Syndrome with Ocular Dryness or Abnormal Ocular Tests

Sjögren syndrome frequently affects the ocular surface. Patients presenting with ocular dryness or objectively abnormal ocular test results represent a specific clinical subgroup requiring a structured, evidence-based treatment approach.

Clinical Scenario

This protocol targets patients with confirmed Sjögren syndrome who present with ocular dryness symptoms and/or abnormal findings on ocular testing. Recognising and treating this manifestation early is important for preserving ocular surface integrity.

Treatment Approach

The protocol includes a patient-derived topical preparation used to address ocular surface involvement in this setting. This biologically-based intervention forms a key component of the management strategy.

The full regimen — including specific preparations, sequencing, and conditions for use — is available in the complete protocol.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1136/annrheumdis-2019-216114

We recommend that all SjS patients presenting with ocular dryness and/or abnormal ocular tests should use AT containing methylcellulose or hyaluronate at least twice daily, with the frequency increased to as often as hourly, as indicated by symptoms and/or objective signs.
The TF recommended that serum tear drops may be considered in patients who are non-responders or intolerant to topical CyA tear drops.

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