Treatment of Sjögren Syndrome in Mothers of Reproductive Age with Anti-Ro/La Antibodies and Fetal or Neonatal Complete Congenital Heart Block

This protocol applies to a mother of reproductive age with Sjögren syndrome who is positive for anti-Ro/La antibodies, where pregnancy is complicated by fetal or neonatal complete congenital heart block — a cardiac conduction finding with recognised prognostic significance in this population.

Ro-associated congenital heart block is a distinct and serious complication linked to maternal anti-Ro/La antibodies in Sjögren syndrome. Although not captured in standard disease-activity scoring (such as the ESSDAI), its prognostic weight necessitates a dedicated management approach beyond routine Sjögren syndrome care.