Treatment of Sjögren Syndrome with Chronic Daily Non-Inflammatory Musculoskeletal Pain

In Sjögren syndrome, musculoskeletal pain is common — but when the pain is chronic, daily, and non-inflammatory in character, it defines a distinct clinical subgroup requiring a fundamentally different management approach.

This protocol addresses Sjögren syndrome complicated by chronic daily non-inflammatory musculoskeletal pain. Because the pain mechanism in this scenario is not driven by active inflammation, strategies that rely on repeated anti-inflammatory agents are not appropriate — a separate therapeutic framework applies.

The treatment approach in this setting draws on oral agents from pharmacological classes used specifically in chronic musculoskeletal pain — not conventional anti-inflammatory therapy. The complete structured regimen, including the specific options and decision pathway, is available via the full protocol.

Partial treatment hint: Oral pharmacological therapy from a specific class of agents indicated for chronic pain conditions may be considered as part of the regimen — the full algorithm and options are in the structured protocol.

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References

DOI: 10.1136/annrheumdis-2019-216114

In patients with chronic, daily non-inflammatory pain, the management must be completely different, avoiding the repeated use of NSAIDs or GCs.

Antidepressants and anticonvulsants may be considered for chronic musculoskeletal pain.

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