This protocol applies to patients with Sjögren syndrome who present with acute musculoskeletal pain or arthralgia. This manifestation requires careful, structured management that accounts for the systemic nature of the underlying disease and the patient's overall comorbid burden.
Acute episodes are addressed with appropriate symptomatic measures, mindful of treatment duration and individual patient factors. For patients experiencing frequent or recurrent episodes, hydroxychloroquine has been proposed as an ongoing oral treatment option — drawing on its established role in related systemic autoimmune diseases. The complete regimen, sequencing, and dosing are available in the full protocol.
DOI: 10.1136/annrheumdis-2019-216114
In patients presenting with acute musculoskeletal pain, consider acetaminophen or NSAIDs for symptomatic relief, always for less than 7-10 consecutive days at full dosage and considering the side effects and underlying comorbid diseases.
In patients with frequent episodes of acute musculoskeletal pain, the use of hydroxychloroquine has been proposed based on its comparable use in other SAD such as systemic lupus erythematosus (SLE).
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