Treatment of Sheehan Syndrome in Premenopausal Women with Central Hypogonadism and Low Serum Estrogens

Clinical Scenario

This protocol addresses Sheehan syndrome presenting in premenopausal females with central hypogonadism characterised by low serum estrogens and oligomenorrhea or amenorrhea.

Specific Situation

In premenopausal females, Sheehan syndrome manifests with low serum estrogens and impaired ovulation, resulting in oligomenorrhea or amenorrhea. These features define the central hypogonadism component that requires targeted management.

Treatment Approach

Gonadal hormone replacement is recommended for premenopausal women with central hypogonadism when no contraindications are present. The appropriate preparation varies according to the patient's clinical situation.

The complete evidence-based regimen — including which preparation to select, the full prescribing rationale, and structured guidance — is available in the protocol below.