Treatment of Sepsis or Septic Shock with Low Risk of Methicillin-Resistant Staphylococcus aureus (MRSA) Infection

Not all patients with sepsis or septic shock carry the same risk of MRSA. When the clinical picture points to a low likelihood of MRSA infection, antimicrobial selection should reflect that risk assessment rather than defaulting to the broadest possible coverage.

This protocol applies to adults presenting with sepsis or septic shock who are assessed as being at low risk of methicillin-resistant Staphylococcus aureus (MRSA) infection.

Antimicrobial Approach

The evidence-based approach for this scenario centres on empiric antimicrobial selection that does not include MRSA-directed coverage — the full protocol specifies which agents and regimens are appropriate for this risk stratum.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1097/CCM.0000000000005337

For adults with sepsis or septic shock at low risk of MRSA, we suggest against using empiric antimicrobials with MRSA coverage, as compared with using antimicrobials without MRSA coverage.

View source ↗