Treatment of Sepsis or Septic Shock with Low Risk for Multidrug Resistant (MDR) Organisms
In adults presenting with sepsis or septic shock, accurate risk stratification for multidrug resistant (MDR) organisms directly shapes empiric antibiotic selection. When MDR risk is assessed as low, the evidence supports a more targeted approach to initial coverage.
Clinical Scenario
Sepsis or septic shock in adult patients with low risk for multidrug resistant (MDR) organisms. Identifying this low-risk profile is the key decision point that determines the breadth of empiric gram-negative coverage required at initiation.
Empiric Treatment Approach
The recommended empiric strategy centres on gram-negative coverage, with evidence guiding the extent of agents used. Current guidance addresses whether broader combination coverage is warranted — or whether a more streamlined approach is preferred in this population.
Full agent selection, sequencing, and clinical algorithm available in the complete protocol →
References
DOI: 10.1097/CCM.0000000000005337
For adults with sepsis or septic shock and low risk for MDR organisms, we suggest against using two gram-negative agents for empiric treatment, compared with one gram-negative agent.
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