Treatment of Sepsis or Septic Shock at High Risk of Fungal Infection

This protocol addresses adults presenting with sepsis or septic shock who are identified as being at high risk of fungal infection — a specific subgroup in whom antifungal coverage requires explicit consideration during initial management.

In adults with sepsis or septic shock at high risk of fungal infection, the evidence-based approach involves empiric antifungal therapy. The full regimen — including agent selection and all clinical decision points — is contained in the complete protocol.