Treatment of Sepsis or Septic Shock with High Risk for Multidrug-Resistant (MDR) Organisms

Adults presenting with sepsis or septic shock in the context of high risk for multidrug-resistant (MDR) organisms represent a distinct clinical population. Standard empiric antimicrobial choices applied to routine sepsis may be insufficient in this setting.

This protocol is for adults with sepsis or septic shock who carry a high risk for multidrug-resistant (MDR) organisms. The presence of septic shock in this group further underscores the need for a deliberate, evidence-guided approach to empiric gram-negative coverage.

Empiric Treatment Approach

Current evidence supports the use of a dual-agent empiric strategy directed at gram-negative pathogens in this population — specific agent selection and the full clinical algorithm are available in the structured protocol.

Instant Access to Structured Evidence-Based Regimens

References

For adults with sepsis or septic shock and high risk for multidrug resistant (MDR) organisms, we suggest using two antimicrobials with gram-negative coverage for empiric treatment over one gram-negative agent.

DOI: 10.1097/CCM.0000000000005337

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