This protocol addresses sepsis complicated by acute respiratory distress syndrome (ARDS) — severe respiratory failure that develops as a direct consequence of the septic process. The presence of ARDS substantially shapes the ventilatory management strategy for these patients.
Ventilatory management in sepsis-induced ARDS involves specific positioning techniques as a key evidence-based intervention. The full structured regimen — including all applicable interventions, their sequencing, and graded evidence — is available in the complete protocol.
Complete clinical decision steps and the full evidence-graded regimen are accessible via the button below.
DOI: 10.1097/CCM.0000000000005337
For adults with sepsis-induced ARDS, we recommend using a low tidal volume ventilation strategy (6 mL/kg), over a high tidal volume strategy (> 10 mL/kg).
For adults with sepsis-induced moderate-severe ARDS, we recommend using prone ventilation for more than 12 hours daily.
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