This protocol is for patients with secondary erythema nodosum whose tender erythematous nodules on the lower extremities have persisted after a prior treatment course. When standard first- and second-line oral agents have failed to achieve nodule resolution, a structured escalated approach is indicated.
The preceding treatment line included agents from the following group:
The defined goal — resolution of tender erythematous nodules on the lower extremities — was not reached with those agents, prompting escalation to this next-step protocol.
When the agents above do not achieve resolution, the escalated approach introduces corticosteroid-based therapy. This may be delivered through a systemic route or, for nodules that remain particularly recalcitrant, through a targeted local intervention. The specific agent selection, full regimen, and clinical decision points are detailed in the complete protocol.
Treatment goal:
Resolution of tender erythematous nodules on lower extremities