Scleredema in Multiple Myeloma, Monoclonal Gammopathy, or Amyloidosis — Treatment Approach
Patients present with symmetrical, woody, non-pitting skin induration of the neck and upper trunk — with the fingers typically spared — in the context of an underlying haematological disease.
This form of scleredema (type 2) is associated with paraproteinaemia, including monoclonal gammopathy, multiple myeloma, and amyloidosis. Identifying the specific lymphoproliferative disorder is a key step in guiding management.
The approach involves physical therapy targeting joint mobility, alongside specialist-directed treatment of the identified haematological condition — the complete structured regimen is available in the full protocol.
References
DOI: 10.1111/jdv.19937
Type 2 scleroedema is associated with haematological diseases like paraproteinaemia including monoclonal gammopathy, multiple myeloma and amyloidosis.
Physical therapy is recommended for all three types of scleroedema, in order to improve the mobility of patients.
In addition, appropriate treatment should be performed if an associated condition could be identified (infection in type 1 scleroedema, a lymphoproliferative disorder in type 2, or diabetes mellitus in type 3).
Therapy of the identified lymphoproliferative disorder in consultation with a haematologist.
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