This protocol addresses sarcoidosis with hepatic involvement presenting with jaundice, cholestasis, and pruritus — a pattern indicating significant hepatobiliary dysfunction in the setting of systemic granulomatous disease.
Hepatic sarcoidosis here is characterised by active cholestasis accompanied by jaundice and skin pruritus, reflecting impaired bile flow and hepatic granulomatous infiltration. This combination warrants a specific treatment strategy directed at the underlying inflammatory process.
Management in this setting involves corticosteroid-based therapy as the primary intervention. When the response is insufficient, combination with a cytotoxic agent is part of the approach. The complete agent selection, sequencing, and follow-up parameters are contained in the full protocol.