Treatment of Sarcoidosis with Hepatic Involvement and Abdominal Pain, Fever, or Significant Liver Function Abnormalities

This protocol applies to patients with hepatic sarcoidosis who are symptomatic — presenting with abdominal pain, fever, fatigue, or constitutional symptoms — or who have significant liver function abnormalities, including abnormal bilirubin or prothrombin time.

Treatment is considered in patients with symptomatic liver disease, such as abdominal pain or jaundice with evidence of cholestasis, significant abnormalities in liver function tests, or frank cirrhosis demonstrated by an elevated prothrombin time.

In cases where hepatic sarcoidosis advances to severe liver involvement despite medical management, a transplant-based intervention may be required. The complete structured regimen — including the full criteria, decision points, and sequence of care — is available via the link below.