This protocol applies to sarcoidosis with hepatic involvement that is symptomatic — presenting with abdominal pain, fever, fatigue, or constitutional symptoms — or where significant liver function abnormalities are present, including abnormal bilirubin or a prolonged prothrombin time.
Granulomatous hepatitis in sarcoidosis warrants treatment in individuals with symptomatic liver disease, particularly those experiencing abdominal pain or signs of cholestasis, or when significant abnormalities in liver function tests are demonstrated, including markedly elevated prothrombin time or evidence of advanced hepatic injury.
Management of symptomatic hepatic sarcoidosis typically involves systemic corticosteroid therapy as the primary intervention.
The specific agent, dosing, taper strategy, and duration are detailed in the full protocol below.
Treatment goal: Improved liver function tests