This protocol addresses patients with sarcoidosis who have developed specific granulomatous skin lesions that are several or generalized in extent — a presentation of cutaneous sarcoidosis where local therapy is no longer sufficient.
When granulomatous skin lesions do not respond to local therapy, or when cutaneous sarcoidosis is more generalized, systemic pharmacotherapy becomes necessary to achieve adequate disease control.
Systemic therapy is required; corticosteroids are typically considered at least in the short term, and steroid-sparing agents are an important part of longer-term management — the complete regimen and sequencing are in the full protocol.