What is the first-line treatment for pain in SAPHO syndrome?

Clinical Scenario

This protocol addresses the first-line management of pain in SAPHO syndrome. Treatment response is evaluated using Visual Analogue Scale (VAS) pain scores as the primary clinical measure.

First-Line Treatment Approach

Oral anti-inflammatory pharmacotherapy is applied as the first-line approach to pain relief, in the absence of contraindications. When initial treatment proves insufficient, add-on options are available — the complete structured regimen is detailed in the full protocol.

Treatment Goal

The primary measurable objective is reduction in pain severity, assessed via Visual Analogue Scale (VAS) pain scores.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1136/rmdopen-2023-003688

Across studies, NSAIDs were usually used as first-line treatment to provide pain relief in SAPHO.

Thus, they may be applied as first-line treatment in the absence of contraindications and supplemented by add-on therapies if not effective.

Of those studies, reporting efficacy of NSAIDs, most focused on pain reduction.

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